Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates
نویسندگان
چکیده
منابع مشابه
Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates.
Short tandem repeats (STRs) are mutation-prone loci that span nearly 1% of the human genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by using capillary electrophoresis and pedigree-based designs. Although this work has provided insights into the mutational dynamics of highly mutable STRs, the mutation rates of most others remain unknown. Here, we harnessed ...
متن کاملPopulation-Scale Sequencing Data Enables Precise Estimates of Y-STR Mutation Rates
1 New York Genome Center, New York, NY 10013, USA 2 Computational and Systems Biology Program, MIT, Cambridge, MA 02139, USA 3 Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02139, USA 4 Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA 5 Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge,...
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We have compared the Y chromosomal lineage dating between sequence data and commonly used Y-SNP plus Y-STR data. The coalescent times estimated using evolutionary Y-STR mutation rates correspond best with sequence-based dating when the lineages include the most ancient haplogroup A individuals. However, the times using slow mutated STR markers with genealogical rates fit well with sequence-base...
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Although the utility of short tandem repeats on the Y-chromosome (Y-STRs) has long been recognized and leveraged in forensics, genealogy and paternity testing, the bulk of these applications have relied on only a few dozen loci identified as having remarkably high mutation rates. Recent efforts have expanded the set of Y-STRs with known mutation rates to two hundred markers, but the limited thr...
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22 23 Y-chromosome microsatellites (Y-STRs) are typically used for kinship analysis and 24 forensic identification as well as for inferences on population history and evolution. All 25 applications would greatly benefit from reliable locus-specific mutation rates, to improve 26 forensic probability calculations and interpretations of diversity data. However, estimates of 27 mutation rate from f...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2016
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2016.04.001